Review calls for better liver fluke models in One Health control

A new systematic review in Science in One Health maps how mechanistic models have been used to study transmission of the liver flukes Clonorchis sinensis and Opisthorchis species, and where those models still fall short. The review, published online March 24, 2026, examined modeling studies identified across six databases through May 14, 2025, with the goal of comparing model structures, assumptions, parameters, and predicted effects of control measures. The authors conclude that existing models have helped clarify the likely value of interventions such as preventive chemotherapy, health education, and environmental improvements, but they also say many models underrepresent spatial heterogeneity, climate effects, and the role of animal reservoirs. (sciencedirect.com)

Why it matters: For veterinary professionals, the review is a reminder that liver fluke control isn't only a human public health issue. WHO notes that dogs, cats, and pigs can act as reservoir hosts for clonorchiasis, and broader reviews of clonorchiasis and opisthorchiasis control also identify animal reservoir management as part of current strategy. That means better modeling could eventually sharpen decisions around surveillance, One Health control programs, and where veterinary interventions fit alongside treatment, food safety, and environmental measures in endemic regions. (who.int)

What to watch: Watch for follow-on models that add animal host data, climate-sensitive transmission inputs, and more localized risk mapping to guide integrated control efforts. (sciencedirect.com)